Introduction of C-28 Side Chain into BA

Extensive research has been conducted to explore the C-28 side chain modifications of BA.30,37,38 A series of C-28 oo-aminoalkanoic acid derivatives of BA, which were first synthesised by Soler et al.,39 functions by blocking the viral entry into the host cells. Incremental chain lengthening significantly influenced the anti-HIV potency of the derivatives.4 Compounds with amide side chains between aminooctanoic acid and aminododecanoic acid (7 11 carbons between the C-28 amide moiety and the terminal carboxylic acid 

4 Bifunctional BA Analogues—Potential for Maturation Inhibitor Development 

Interestingly, the anti-HIV-1 targets of triterpene analogues can vary depending on the side chain modification positions.21 Some C-28 modified BA analogues are potent HIV entry inhibitors, while some C-3 modified BA derivatives 

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