Intravenous self-administration test

The development of some of the secondary models such as conditioned place preference and electrical brain stimulation which do not require intravenous drug injections will continue to occur (for complete descriptions of the conditioned place preference paradigm and validation data, see Bardo and Bevins (2000) or Cunningham et al. (2006, 2011) for a complete description of the electrical brain stimulation model, also see O Neill and Todtenkopf (2010) or McBride et al. (1999)). A better understanding of the predictivity of these models and correlation with the traditional self-administration model will be required for these models to assume a mainstream position in abuse potential assessment. The self-administration model s predictive correlation to abuse potential in humans has been well characterized but new models will have to be characterized and published to have equal impact in future abuse potential testing. 

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