Intravenous immunoglobulin hemolysis

Severe acute hemolysis due to acquisition of red cell alloantibodies from donor serum has been reported (67-69). In other cases, the suggested mechanism of hemolytic anemia after high dosages of intravenous immunoglobulin was the presence of anti-A and/or anti-B antibodies in the plasma product (70). 

The authors considered it probable that the patient s AB blood type had increased the risk of hemolysis and they concluded that patients with severe hemolysis can switch from one batch of intravenous immunoglobulin to another batch of the same product after recovery. 

Padmore RF. Hemolysis upon intravenous immunoglobulin transfusion. Transfus Apher Sci February 2012 46(l) 93-6. 

Rink BD, Gonik B, Chmait RH, O Shaughnessy R. Maternal hemolysis after intravenous immunoglobulin treatment in fetal and neonatal alloimmrme thrombocytopenia. Obstet Gynecol February 2013 121(2 Pt 2 Suppl l) 471-3. 

Shakouri AA, Bahna SL. Acute hemolysis secondary to high-dose intravenous immunoglobulin in a patient with Stevens-Johnson syndrome. Aim llergy Asthma Immunol official Publ Am CoU Allergy, Asthma, Immunol June 2012 108(6) 463-. ... 

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