Multiple dosing intravenous bolus administration

Multiple dosing intravenous bolus administration Steady-slate plasma concentration... 

This expression, which relies on fairly rapid absorption such that each subsequent dose is administered in the post-absorptive phase, can be readily employed to determine the extent of accumulation following extravascular administration of a drug as long as dosing interval and the elimination rate constant of the drug are available. Note the similarity between Eq. 12.27 for multiple oral dosing and Eqs 11.29,11.33 and 11.34 for multiple intravenous bolus administration. 

Figure 11.8 Plasma concentration (Cp) versus time profile following the administration of a single dose and multiple doses of a drug as intravenous bolus, min, minimum max, maximum av, average.

---