Intrahepatic cholangiocellular carcinoma

Immunohistochemistry has been used for investigating the expression of HER-2-4 in 38 intrahepatic cholangiocellular carcinomas (Ito et al., 2001). HER-2 expression was observed in more than 50% of the cases but was not related to any clinicopathological features. HER-3 expression was linked to lymph node metastasis, and HER-4 expression was directly related to proliferating activity and lymph node metastasis. 

Ito, Y., Takeda, T., Sasaki, Y., Sakon, M., Yamada, T., Ishiguro, S., Imaoka, S., Tsujimoto, M., Higashiyama, S., Monden, M., and Matsuura, N. 2001. Expression and clinical significance of the erbB family in intrahepatic cholangiocellular carcinoma. Pathol. Res. Pract. 197 95-100. 

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