Intracellular bacteria Listeria monocytogenes

De Cliastellier C, Berche P Fate of Listeria monocytogenes in murine macrophages Evidence for simultaneous killing and survival of intracellular bacteria. Infect Immun 1994 62 543-553. 

We have shown that oral administration with hot water extracts (CVE) significantly augmented the host defense against infection with Listeria monocytogenes (L. monocytogenes) [10]. L. monocytogenes is one of an intracellular bacteria, as well as Mycobacterium tuberculosis [11-12]. The protective mechanism against Listeria infection depends mainly on the immune response mediated by ap T cells [13]. 

In contrast to the above data Listeria monocytogenes infection of J774 cells shows a different pattern of bacterial protein synthesis. None of the thirty-two proteins observed for intracellular bacteria are induced by typical in vitro stress conditions, including heat shock and oxidative stress (Hanawa et al, 1995). This observation would be consistent with the intracellular bacteria rapidly migrating from the phagosome to the cytoplasm during intracellular growth. 

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