Intracellular antioxidants and atherosclerosis

Some of the decomposition products of lipid peroxidation, such as aldehydes, are extremely cytotoxic and it has been shown that these are formed within atherosclerotic 

It appears then that both intracellular and extracellular antioxidants may be important in the prevention of atherosclerosis. The progression of a lesion may signify that these protective pathways are overwhelmed. 

Aikens, J. and Dix, T.A. (1991). Perhydroxyl radical initiated lipid peroxidation. J. Biol. Chem. 266, 15091-15098. 

Jacobs, H.S., Eaton, J.W., Belcher, J.D. and Vercel-totti, G.M. (1991). Hemin a physiological mediator of low-density lipxjprotein oxidation and endothelial injury. Arteriosclerosis 11, 1700-1711. 

Beckman, J.S., Beckman, T.W., Chen, J., Marshall, P.A. and Freeman, B.A. (1990). Apparent hydroxyl radical production by pjeroxynitrite implications for endothelial injury from nitric oxide and superoxide. Proc. Nad. Acad. Sci. USA 87, 1620-1624. 

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