Intra- Cellular Receptor Localization

In MCMV infected macrophages and fibroblast, M78 is mainly localized inside the cells in vacuole like structures which colocalizes with markers for medial and peripheral Golgi bodies. Furthermore, M78 is present in virus preparations, and is as a possible virion envelope protein, presumably delivered to newly infected target cells. M78 has been proposed to be involved in modulating the intracellular milieu and regulating the transcription of selected immediate early viral mRNAs.  

U51 (from HHV6) transiently expressed in human monolayer cells (HEK293 or l43tk) could not be detected in the plasma membrane, but was found to accumulate in a reticular pattern partially overlapping with ER-staining. However, the cellular localization U51 seems to be cell type dependent. In transfected T-ceU lines (J-Jahn, Molt-3 and Jurkat cells) and in infected cord blood mononuclear cells, U51 seems to localize to the plasma membrane.  

---