Interstitial nephritis trimethoprim-sulfamethoxazole

Richmond JM, Whitworth JA, Eairley KE, Kincaid-Smith P. Co-trimoxazole nephrotoxicity. Lancet. 1979 Mar 3 1 (8114) 493. Kraemer MJ, Kendall R, Hickman RO, Haas JE, Bierman CW. A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. Annals of allergy. 1982 Dec 49(6) 323-5. 

Smith EJ, Light JA, Eilo RS,Yum MN. Interstitial nephritis caused by trimethoprim-sulfamethoxazole in renal transplant recipients. Jama. 1980 Jul 25 244(4) 360-1. 

Kraemer MJ, Kendall R, Flickman RO, Flass JE, Bierman CW. A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. Ann Allergy 1982 49 323-325. 

The mechanism differs from that underlying the sulfamethoxazole/trimethoprim interaction. Sulphonamides such as co-trimoxazole and sulfadiazine are known to cause renal dysfunction - interstitial nephritis and renal failure, which may -L excretion of methotrexate. Sulphonamides are also known to compete with methotrexate for renal elimination. Displacement from protein-binding sites of methotrexate is a minor contribution to the interaction... 

SmifliEJ, Light JA FiloRS, Yum MN. Interstitial nephritis caused ly trimethoprim-sulfamethoxazole in renal tmn lant recipients. JAMA (1980) 244,360-1. 

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Garvey JP, Brown CM, Chotirmall SH, Dorman AM, Conlon PJ, Walshe JJ. Trimethoprim-sulfamethoxazole induced acute interstitial nephritis in renal allografts clinical course and outcome. Clin Nephrol 2009 72(5) 331-6. 

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