Tautomerism intermolecular

The first observation of the proton transfer in pyrazoles in the solid state was made for the intermolecular tautomerism in 3,5-dimethylpyrazole 10b (85JA5290). The degenerate rearrangement was recorded using the... 

Bassan et al. (117) studied the intermolecular tautomerization of 2,4-cyclohexadienone and the associated barriers using one... 

Tautomeric equilibria have been studied in nitrosophenols. An early study of 4-nitroso-phenol showed an intermolecular tautomerism catalysed by slight traces of water. In dry dioxane both the Af-oxide and the oxime form could be observed . ... 

Figure 3.2 Examples of molecular systems enabling amino-imino (NH/N) tautomerization (a) Intramolecular direct photo-tautomerization 2-(2 -pyridyl)pyrrole (1), 2,9-(di-2 -pyridyl)-4,7-di(4ert-butyl)carbazole (2), porphyrin (3), porphycene (4). (b) Intermolecular tautomerization in doubly...

Examples of Intermolecular Tautomerizations in the Presence of Pre-Equilibria without Requiring Major Reorganization of the Environment... 

A well-known example of non-prototropic tautomerism is that of azolides (acylotropy). The acyl group migrates between the different heteroatoms and the most stable isomer (annular or functional) is obtained after equilibration. In indazoles both isomers are formed, but 2-acyl derivatives readily isomerize to the 1-substituted isomer. The first order kinetics of this isomerization have been studied by NMR spectroscopy (74TL4421). The same publication described an experiment (Scheme 8) that demonstrated the intermolecular character of the process, which has been called a dissociation-recombination process. 

Hydroxypyridine 1-oxide is insoluble in chloroform and other suitable solvents, and, although the solid-state infrared spectrum indicates that strong intermolecular hydrogen bonding occurs, no additional structural conclusions could be reached. Jaffe has attempted to deduce the structure of 4-hydroxypyridine 1-oxide using the Hammett equation and molecular orbital calculations. This tautomeric compound reacts with diazomethane to give both the 1- and 4-methoxy derivatives, " and the relation of its structure to other chemical reactions has been discussed by Hayashi. ... 

The above value for R = H corresponds to an intermolecular process, either assisted by the solvent (in solution) or by other NH-pyrazole molecules (in solution and in the solid state) while metal migrations are probably intramolecular (the bigger the metal, the easier) and those of COR correspond (for R = NHR ) to a dissociation-recombination mechanism. Minkin [quoted in 96MI(15)339] suggests that a tautomeric process should... 

X-Ray analyses and solid-state IR spectra were recorded for a number of 1,4-and 1,6-dihydropyrimidines, demonstrating the dependency of the tautomeric composition in the crystal on the substitution in the pyrimidine ring and on the ability of these compounds to form intermolecular hydrogen bonds. Thus,... 

Moreover, with a change of solvent, a new tautomeric form can arise owing to formation of intermolecular hydrogen bonds in place of the previously existent intramolecular hydrogen bonds. This situation is characteristic, for example, for pyrimidine derivatives 49, for which the use of polar (DMSO, DMF, MeOH, HMPT) solvents or specifically solvating cosolvents (S) (e.g., a small amount of water or A-methylpyrrolidinone) leads to the appearance of ylidene tautomer 49b with the p-quinonoid disposition of the double bonds (Scheme 18) [88KGS521 90UK457]. 

In 1992, Bergman et al. reported that zirconium bisamides Cp2Zr(NHR)2 catalyze the intermolecular hydroamination of alkynes with sterically hindered primary amines to give enamines or their tautomeric imines (e.g., Eq. 4.77) [126]. 

The aggregation behaviour and tautomerism of three 0,0 -dihydroxy and one o-hydroxy-o -methoxy monoazo dyes have been studied by UV-visible spectroscopy [17]. Evidence of monomer-dimer equilibria was obtained for all four of these mordant dye structures. Intermolecular hydrogen bonding between the hydroxy groups and hydrophobic interaction between aryl nuclei contribute to the dimerisation effect. 

For the diazine 52 there are three tautomeric forms conceivable. When R = C02Et, 53, the situation is complicated by the possibility of an additional pathway for tautomerism. The IR results for this system are in fact ambiguous, and the investigators mention the possibility of cooperative intermolecular proton transfer being responsible for broad bands in the spectrum (111). 

The solid-solid transformation of 2-amino-3-hydroxy-6-phenylazopyridine, 57a, to 57b proceeds through two intermediate phases (119). X-Ray and IR studies of the former, low-temperature, and the latter, high-temperature phase show that they are the phenolazo and quinone hydrazone forms, respectively. This solid-state tautomerism can be accounted for by a cooperative intermolecular shift of protons across the various hydrogen bonds. However, because of the complexity of the hydrogen-bond network, the actual pathway of the proton shift has not been uniquely defined. 

The rapid tautomerism due to the intermolecular exchange of protons between two N atoms in azoles can be slowed down by using DMSO as solvent to such an extent that even at room temperature different signals appear. 

In a study of tautomeric heterocycle systems Zubatyuk et al. [39] concluded that the position of tautomeric equilibrimn is controlled by the aromaticity of the heterocycle. They have also shown a strong correlation between the strength of the a intramolecular hydrogen bond and the aromaticity of a resonant spacer. In DPGUAN03, where two symmetry independent molecules, establish similar hydrogen bonds, the lowest aromaticity corresponds to the strongest intermolecular H-bonds. 

There are several reports in the literature dealing with the bimolecular [3 + 2] cycloaddition reactions of alkynyl-substituted diazo compounds. Propargyl diazoacetate 212, when stored for 2 weeks at 0 °C, was transformed into an oligomer to which the constitution 213 was assigned (273) (Scheme 8.50). The alkynyl-diazoketone 214 requires a much higher temperature and is transformed into pyrazole 215, which probably arises from intermolecular cycloaddition, pyrazole tautomerization, and carbenic N/H insertion (274). The inter-intramolecular... 

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