Intermittent drug release

Nonsteroidal anti-inflammatory drugs ibuprofen, ketoprofen, naproxen sodium Alternative mefenamic acid, cyclooxygenase-2 inhibitors, acupuncture, oral contraceptives, triptans, intermittent 17y6-estradiol, gonadotropin-releasing hormone agonist estrad iol/progesterone add-back therapy Insomnia... 

Another nonbarbiturate anesthetic is the imidazole carboxylate etomidate. Even though it produces no analgesia, it is used with fentanyl (see later) to produce very rapid anesthesia induction. The drug s appeal is its minimal effect on respiration and the cardiovascular system. Unlike many of the volatile compounds, it produces no annoying histamine release. It does cause intermittent muscle twitching. 

Short-term administration of barbiturates has no clinically significant effect on the hepatic, renal, or endocrine systems. A single induction dose of thiopental does not alter tone of the gravid uterus, but may produce mild transient depression of newborn activity. Drug-induced histamine release is occasionally seen. Barbiturates can induce fatal attacks of porphyria in patients with acute intermittent or variegate porphyria and are contraindicated in such patients. Unlike inhala-tional anesthetics and succinylcholine, barbiturates and all other parenteral anesthetics apparently do not trigger malignant hyperthermia. 

Both, in vitro and in vivo, adjustable slow, rapid, or intermittent release of drug molecules in the porous Si02 film could be triggered by an applied magnetic field. 

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