Intermediate lobe dopamine receptor

The D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland... 

Dopaminergic neurons synapse upon the parenchymal cells of the intermediate lobe (IL) of the rat pituitary gland. Dopamine decreases the capacity of the IL cells to synthesize cyclic AMP and inhibits the release of otMSH and other peptides from this tissue. The presence of a D-2 receptor accounts for both of these phenomena. This D-2 dopamine receptor can be studied in a binding assay using [3H]-spiroperidol, a dopamine... 

The dopamine receptor in the intermediate lobe of the pituitary gland is negatively coupled to adenylate cyclase... 

In this volume a good deal of emphasis is placed on studies of dopamine receptors in pituitary. This emphasis seems well justified. The clear-cut effects of dopamine in suppressing prolactin secretion from anterior lobe mammotrophs, and the inhibitory effects on secretion of a-MSH and related secretory products from intermediate lobe are important models for dopamine receptor studies. In both cases new evidence was put forward to support the hypothesis that the actions of dopamine on the secretory cells are mediated by inhibition of adenylate cyclase. This is far easier to demonstrate in the intermediate lobe, where all cells appear to respond to dopamine, than in the anterior lobe, where the dopamine-sensitive cells probably represent only a small minority. 

Cote TE, Eskay RL, Frey EA, Crewe CW, Munemura M, Stoof JC, Tsuruta K, Kebabian JW (1982) Biochemical and physiological studies of the beta-adrenoceptor and the D-2 dopamine receptor in the intermediate lobe of the pituitary gland a review. Neuroendocrinology 35 217-224. 

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