Interleukin-1 , ferritin translation

For our model system, hepatic ferritin gene expression was monitored in response to interleukin-1 (IL-1) [71]. IL-1 was found to significantly increase ferritin translation by signaling though a novel translation enhancer element, the acute box motif, downstream from the IREs at the 5 cap site [45, 72]. This acute box motif is located immediately downstream from Iron-responsive Element in the 5 untranslated regions of both the L- and H-ferritin transcripts [73], and was also found to be present in front of the start codon in the APP transcript [47]. This observation was consistent with the pattern of both APP and ferritin expression in response to inflammation during both Alzheimer s disease and the anemia associated with chronic disease. 

Rogers JT. Ferritin translation by interleukin-6 the role of sequences upstream of the start codons of the heavy and light subunit genes. Blood 1996 87 2525-2537. 

Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN. Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem 1990 265 14572-8. 

Rogers, J.T., et al.. Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5 leader sequences distinct from the iron responsive element. Nucleic Acids Res, 1994.22(13) p. 2678-86. 

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