Interhalogens, replacement

The only direct replacement of a proton by a substituent is the halogenation of 1,2,3-triazines I.79-106 Best results (67%) were obtained in the reaction of 4,6-dimethyl-l,2,4-triazine (1, R1 = R2 = Me) with bromine lower yields were obtained with chlorine and the interhalogens. No halogenation was observed with iodine. The unsubstituted (1, R1 = R2 = H) and 4-methyl-... 

The chemical properties of the interhalogens have been studied more fully than the chemical properties of the polyhalides. Their useful reactions depend upon the ability of the interhalogens to halogenate. In organic reactions, for example, it is possible to replace the chlorine atom in carbon tetrachloride with fluorine atoms through the use of bromine trifluoride. 

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