Interferon beta Theophylline

Interferon beta reduced theophylline clearance by 29% in seven patients (SED-13, 1099). [Pg.1836]

Theophylline clearance is reduced by up to 50% by interferon aifa and by about 25% by interferon beta. [Pg.1184]

Seven patients with chronic hepatitis C receiving interferon beta 3 to 9 million units daily for 8 weeks were given a single 250-mg dose of intravenous aminophylline. Interferon beta reduced the total body clearance of theophylline by 26% (range 5.8 to 57%) and increased the elimination half-life by 39% (range 27 to 139%), but had no significant effect on the volume of distribuhon, although there was wide inter-patient variability. ... [Pg.1184]

Interferon alfa inhibits the liver enzymes concerned with the metabolism of some drugs, such as theophylline. Therefore the metabolism of theophylline is reduced, and it accumulates. Interferon beta also appears to inhibit liver enzymes. ... [Pg.1184]

Agents that may increase theophylline levels include allopurinol, beta blockers (nonselective), calcium channel blockers, cimetidine, oral contraceptives, corticosteroids, disulfiram, ephedrine, influenza virus vaccine, interferon, macrolides, mexiletine, quinolones, thiabendazole, thyroid hormones, carbamazepine, isoniazid, and loop diuretics. [Pg.738]

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