Integrins heterodimers

Interference with specific cell-cell and cell-matrix adhesion mechanisms is another rapidly advancing approach to therapeutically interfere with angiogenesis. Antagonistic antibodies (Vitaxin) to the integrin heterodimer av 33 have been shown to act on the blood vessels of tumors but not on the resting organ vasculature. Vitaxin demonstrated some promise in Phase II clinical trials. 

A. Overall Picture of Integrin Heterodimers and Integrin Domains. 31... 

Stewart etal., FIg. 12. The interaction between the integrin proximal domain and the Adl2 penton base protein. (A) The integrin density is shown extracted along estimated boundaries to model the proximal domain of one integrin heterodimer and shown with the penton base and fiber. (B) The modeled proximal domain rotated to showtheinteractionwithasingle penton base protrusion. (G) The same view as in (B),but with the protrusion removed to reveal the RGD-binding cleft. The color scheme is the same as in Fig. 11. Scale bars 25 A. [Reproduced with permission from Chiu etal. (1999).]... 

Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A. and Damsky, C.H. (1990) The alpha-1 beta-1 and alpha-6 beta-1 integrin heterodimers mediate... 

Ignatius, M.J. and Reichardt, L.F. (1988) Identification of a neuronal laminin receptor an M 200K/120K integrin heterodimer that binds laminin in a divalent cation-dependent manner. Neuron 1 713-725... 

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