Integration of Metabolism Cellular Signaling

Protein kinases and phosphatases play vital roles in intracellular signaling pathways and in the integration and control of major cellular processes. Kinases and other phosphoryl group transferases are essential in the metabolism of lipids, nucleotides, and other small biomolecules. The use of SBDD methods on such targets has expanded as more of their X-ray structures have been solved, and will continue to grow as more targets are validated for their involvement in human diseases. 

---