Insulin release curve

Figure 3. HPLC release curves for insulin imbibed into (a) poly(methacrylic acid) and (b) poly(acrylic acid).

It is very likely that the solubility and rates of absorption of sulfonylureas influence the contours of their hypoglycemic curves (20, 28). It is also possible that differences in metabolism affect their acute potencies. Nevertheless, it is likely that the known sulfonylureas act via the same mechanism—i.e., via f3 cell stimulation with release of insulin (5). The spectrum of activity of all the current sulfonylureas seems to be virtually identical—i.e., their effectiveness as sole hypoglycemic therapy is limited to the maturity-onset type of diabetic. 

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