Insulin metabolism heparin

A 23-year-old diabetic woman had severe subcutaneous insulin resistance for 11 years (169). Continuous subcutaneous insulin infusion with regular or insulin lispro did not prevent periods of fluctuating responses to insulin. The addition of heparin to insulin lispro in the pump improved serum insulin concentrations and metabolic control. The addition of heparin to regular insulin gave no improvement. 

Lipids have an adverse effect on carbohydrate metabolism under basal conditions. The infusion of 20% triglyceride emulsion with heparin during basal insulin and glucose turnover conditions resulted in a rise of plasma free fatty acids from 0.4 to 0.8 mmol/1 at a low rate of infusion (0.5 ml/minute for 2 hours) to between 1.6 and... 

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