Insulin hypersecretion

Sugiyma et al. (1992) found a reduction of glucose intolerance and hypersecretion of insulin in Wistar fatty rats after treatment with pioglitazone for 10 days. 

Eerrannini E, Natali A, Bell P, et al. On behalf of the European Group for the Study of Insulin Resistance (EGIR). Insulin resistance and hypersecretion in obesity. J Clin Invest 1997 100 1166-1173. 

Inappropriate hypersecretion of insulin causes hyperinsulinism (HI). There are a number of causes of HI but the most common are due to inactivating mutations in the Katp channel genes (KCNJll and ABCC8) which encode Kir6.2 and SURl, respectively. HI can also be caused by activating mutations in the glucokinase (GCK) gene (Table 24.2 and Fig. 24.1). 

LaBarre J, de Cespedes C. Role du systeme nerveux central dan I hypersecretion gastrique consecutive a I adminstration d insuline. C R Soc Biol Paris 106 1249-1251,1931. 

There is a mouse strain that is resistant to insulin, which is characterized by the hypophyseal hypersecretion of growth hormone (Roos et al., 1974). 

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