Insulin human Mixtard

Biphasic insulins are fixed dose combinations of a short-acting and intermediate-acting insulin in various proportions. Examples are Humulin, a biosynthetic human insulin (rDNA origin) suspension with respectively 20%, 30% and 40% regular and 80%, 70% and 60% isophane insulin and Mixtard, a biphasic biosynthetic human insulin suspension with respectively 10%, 20% and 40% soluble and 90%, 80% and 60% isophane insulin. 

A 6-year-old boy developed recurrent generalized urticaria 1 year after he started to use human Mixtard insulin (132). The rash started 10 minutes after injections in the arms, thighs, and buttocks, at sites where earlier injections had been given, and disappeared within 12 hours. When he was changed to insulin lispro he had three urticarial reactions in the first 2 weeks and then sporadically. The reactions were treated with chlorphenamine for 2 years. 

Actrapid/Velosulin/ Monotard/ Insulatard/ Protaphane/ Mixtard/ Actraphane/ All contain recombinant human insulin produced in S. cerevisiae formulated as short/ intermediate/long acting product) Identical to native human insulin Novo Nordisk 2002 (EU)... 

Mixtard, human 70% NPH 30% regular premix (Nordisk) Long-Acting Insulins Standard 100 Human, semisynthetic... 

Isophane Insulin Suspension and Insulin Injection 0.25 -1 24 Mixtard Novolin 70/30 (human). 

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