Insulin Hexokinase theory

Effect of Insulin on Individual Enzymes and Multiple-Enzyme Systemes Hexokinase Theory... 

The hexokinase theory originally rested on four groups of experimental observations (1) insulin s ability to relieve the inhibition of crude hexokinase activity caused by extracts of the anterior hypophysis or the adrenal cortex (2) indirect evidence that insulin activates hexokinase in vivo (3) the existence of hexokinase inhibitors in the blood of diabetic animals and (4) the absence of an effect of insulin on pathways that bypass the hexokinase reaction. In discussing the... 

The hexokinase theory originated from experiments by Colowick, Cori, and Slein [128]. The combined effects of three hormones—an anterior pituitary extract, an adrenocortical extract, and insulin— were studied on crude or purified hexokinase preparations obtained from kidney, brain, liver, and heart of normal and alloxan-diabetic rats. We shall first present the results obtained on normal rats, and then those obtained on diabetic rats. 

Bessman, S. P., and Gots, R. E., 1975, The hexokinase acceptor theory of insulin action— hormonal control of functional compartmentation. Life Sci. 16 1215. 

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