Instrument Qualification coupling

In this chapter we focus primarily on calibration of LC-MS where the mass spectrometer is operating at unit resolution, resolution that is sufficient to separate two peaks one mass unit apart. This kind of low-resolution mass filter covers almost 90 percent of the instruments commonly used for qualitative and/or quantitative analysis of small molecules. Batch-to-batch qualification testing of the instrument is also described. For the calibration of high-resolution mass spectrometers such as magnetic sector, TOF, or FTICR coupled with liquid chromatography, readers are referred to specific publications. [Pg.198]

International Conference on Harmonization inductively coupled plasma inner diameter, identification instrument detection limit ion-exchange chromatography ion-interaction chromatography installation qualification isopropyl alcohol ion-pair chromatography infrared (detector)... [Pg.221]