Insect-growth regulators analogs

Compounds that mimic the action of JHs could also be used as insecticides. In fact, numerous JH analogs were derived among which methoprene. This ligand, used commercially as an insect growth regulator, closely resembles JHs, but lacks the epoxide func-... 

CAS 8003-34-7. Any of a group of insect growth regulators that act as neurotoxins, analogous to juvenile hormones, restricting the development of insect larvae. Thus they are especially effective against insects that are destructive in the adult stage. They are considered nontoxic to animals and humans. 

For the last two decades, in order to develop insecticides with selective toxicity, efforts to identify mimics (agonists) of 20-hydroxyecdysone, the insect molting hormone, have always led to the use of ecdysteroids or closely related steroidal analogs which are not commercially cost-effective. Recently, a new class of insect growth regulators, the 1,2-diacyl-l-alkylhydrazines, has been discovered and shown to be the first nonsteroidal agonists of 20-hydroxyecdysone. 

It has been demonstrated that 1,2-diacyl-l-alkylhydrazines represent a new class of selective insecticides in which RH-5849 and its structurally related analogs proved to be the first nonsteroidal mimics of 20-hydroxyecdysone insect molting hormone. Hopefully, by using this and other new insect growth regulators, we can gradually reduce our dependence on the conventional insecticides which have given us many problems related to the environmental impact. 

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