Insect central nervous system

Mode of Motion. Nicotine, anabasine, and imidocloprid affect the ganglia of the insect central nervous system, faciUtating transsynaptic conduction at low concentrations and blocking conduction at higher levels. The extent of ionisation of the nicotinoids plays an important role in both their penetration through the ionic barrier of the nerve sheath to the site of action and in their interaction with the site of action, which is befleved to be the acetylcholine receptor protein. There is a marked similarity in dimensions between acetylcholine and the nicotinium ion. 

Lummis SCR, Buckingham SD, Rauh JJ, et al. 1990. Blocking actions of heptachlor at an insect central nervous system GABA receptor. Proc R Soc Lond [Biol] 240 97-106. 

Acts as an antagonist by binding to post-synaptic nicotinic receptors in the insects central nervous system... 

To obtain clearer understanding of the behavioral effects of reserpine and their possible relationship to levels of aromatic biogenic amines in the insect central nervous system, we injected unfed, 2-day old adult P. regina with 2 yig/fly of reserpine. 

GABA Receptors of the Insect Central Nervous System... 

The pharmacology of insect central nervous system transmitter receptors and their associated modulatory sites and ion channels is less thoroughly known than that of the peripheral neuromuscular systems. This is in part due to the relative inaccessibility of the central... 

Of the most-used insecticides, the chlorinated hydrocarbons bring about death by initially stimulating and then exhausting the nervous system. The insect central nervous system consists essentially of a double nerve cord situated ventrally and punctuated by segmental ganglia from which the peripheral nerves arise. The axon of such a nerve measures up to 10 pm in diameter and is enclosed in a thin non-myelinated lipoprotein sheath. These axons are bundled into nerves which are surrounded by dove-... 

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