Injectable biodegradable materials

Key words biodegradability, sol-gel transition, thermosensitivity, hydrogel, block copolymer, in-situ gelation, drug debvery system. 

A gel duration from a week to several months was realized by topological variation of the PEG/PLGA copolymer system. The PEG-g-PLGA showed one week of gel duration, whereas PLGA-g-PEG showed more than three months of gel duration, even though the composition of the two polymers was similar. 

The thermogelling PLGA is an amorphous polymer with a low glass transition temperature. Therefore, the PEG/PLGA copolymer systems of which 

2 Schematic presentation of the structure of PLGA-g-PEG and PEG-g-PLGA. Thick black bars and wavy gray lines indicate the hydrophobic PLGA and hydrophilic PEG, respectively. 

3 Differential scanning calorimeter thermogram of PEG-PCL-PEG (550-2100-550) (with permission from American Chemical Society). 

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J. Temenoff, A. Mikos, Injectable biodegradable materials for orthopedic tissue engineering. Biomaterials 21 (2000) 2405-2412. 

The context of this chapter aims to discuss the most recent advances in the use of injectable biodegradable materials for bone tissue engineering. The current clinical need, design criteria, and material property requirements were illustrated followed by an overview of the latest material, cellular, and drug... 

Under the Mater-Bi trademark, Novamont produces different classes of starch-based biodegradable materials and blends of starch with synthetic polymers. Each class is available in several grades to meet the needs of specific applications. Classes include grades for film and sheet extrusion, injection moulding and foams. 

Krasko, M.Y., Domb, A.J., 2007. Pasty injectable biodegradable polymers derived from natural acids. Journal of Biomedical Materials Research Part A 83, 1138—1145. 

MAJOR PRODUCT APPLICATIONS biodegradable materials, bulk molding, calendering, coatings, composites, containers, cosmetics, disposable articles, extruded products, films, inl, injection molding, in-mold coating, lacquers, molded articles, pharmaceuticals, seals, sheet ... 

Thermoplastic starch (TPS) is a relatively new concept and today, it is a primary researchy focus for the manufacture of starch-based biodegradable materials (Averous, 2004). Native starch is not thermoplastic, but in the presence of a plasticizer (water, glycerol, sorbitol, etc.), high temperature, and pressure, it melts and fluidizes, enabling its use in injection, extrusion and blowing equipment, just like synthetic plastic materials. 

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