Inhibitors of viral protein synthesis

The principal compounds that act as inhibitors of viral protein synthesis are the interferons. These compounds are members of a naturally occurring family of glycoprotein hormones (RMM 20 000-160 000), which are produced by nearly all types of eukaryotic cell. Three general classes of interferons are known to occur naturally in mammals, namely the a-interferons produced by leucocytes, P-interferons produced by fibroblasts and y-interferons produced by T lymphocytes. They form part of the human immune system. It is believed that the presence of virons and pathogens in the body switches on the mRNA that stimulates the production and release of interferons. These interferons are thought to stimulate the production of proteins that inhibit the synthesis of viral mRNA and viral proteins. a-Interferons also enhance the activity of T killer cells. 

The formation and release of interferon by viral and other pathological stimulation has resulted in a search for chemical inducers of endogenous interferon. Administration of a wide range of compounds has resulted in induction of interferon production. However, no clinically useful compounds have been found for humans, although tilorone is effective in inducing interferon in mice. 

SELECTED EXAMPLES OF DRUG ACTION AT SOME COMMON TARGET AREAS 

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Interferon is a non-specific inhibitor of viral protein synthesis and has both antiproliferative... 

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