Inhibitors of cellulose biosynthesis

Genetic Mutations, and Chemical Inhibitors of Cellulose Biosynthesis. . 143... 

Polyoxins are inhibitors of chitin biosynthesis. Chitin is a component of fungal cell walls except in Phycomycete fungi these contain cellulose as their major cell wall constituent, hence polyoxins are inactive against Plasmopara, Pythium and Phytophthora. 

The lA -l,2,4,6-thiatriazines 276 act as very potent inhibitors of the biosynthesis of cellulose and as such have been extensively investigated as a novel class of herbicides <20030725, 1996WO9601814, 1997W09725318, 1997W09725319, 1998WO9808845>. 

A proteinaceous inhibitor of rubber biosynthesis was purified from the C-serum of Hevea brasiliensis latex. The protein inhibited the incorporation of isopentenyl diphosphate into rubber. Purification was achieved by employing three column chromatography methods Sephadex G-150 gel filtration, DEAE-Cellulose ion exchange chromatography and Phenyl Sepharose CL-4B hydrophobic interaction chromatography. 21 refs. 

Further support for cell wall biosynthesis as a target site was provided by Umetsu et al, who reported abnormal swelling of cultured soybean cells treated with dichlobenil. Dichlobenil was also shown to be an effective and reversible inhibitor of cell wall formation in tobacco protoplasts. It was considerably more potent than other cell wall inhibitors, such as coumarin, and it caused the formation of multinucleate protoplasts. Inhibition of cellulose biosynthesis prevented cell wall formation and cytokinesis but nuclear division that is, mitosis was unaffected. Further studies with tobacco protoplasts confirmed the specific and potent inhibition associated with the cellulose-synthesizing complex at the plasma membrane. 

Another lignocellulose. Zinnia elegans, has been analyzed for the presence of cellulose and lignin, and for the effect of the cellulose inhibitor on lignin biosynthesis... 

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