Inhibitors and Other Factors Influencing the Activity

Cholinesterase Inhibitors and Other Factors Influencing the Activity 

Cholinesterases belong to the group of hydrolases splitting the ester bond, 

According to the affinity to natural substrates choline esters cholinesterases are divided into AChE and BuChE. AChE, specific or true cholinesterase, the e type of cholinesterase (EC 3.1.1.7) has a higher affinity to acetylcholine than to butyrylcholine, and splits acetyl-beta methylcholine. 

AChE and BuChE differ in their enzymatic properties and physiological function (M7, D4). However, there are other types of cholinesterases like benzoylcholinesterase and propionylcholinesterase. AChE splits neuromediator acetylcholine at the cholinergic synapses. It was also observed in erythrocytes but its function here is not yet known in detail. Like the function of BuChE activity in plasma, though, there is evidence that BuChE plays an important role in cholinergic neurotransmission and could be involved in other nervous system functions, in neurological diseases, and in nonspecific detoxification processes (D4). 

A more detailed knowledge of cholinesterases occurred with the description of the molecular structure of AChE (S26) and it is described in greater 

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