Inhibition proactive

Schematic representation of the fibrinolytic system. Plasmin is the active fibrinolytic enzyme. Several clinically useful activators are shown on the left in bold. Anistreplase is a combination of streptokinase and the proactivator plasminogen. Aminocaproic acid (right) inhibits the activation of plasminogen to plasmin and is useful in some bleeding disorders. t-PA, tissue plasminogen activator.

Note In fibrinolysis, plasmin, an endopeptidase that is converted from plasminogen by an activator, hydrolyzes fibrin, fibrinogen, factor V, and factor VIII to their inactive products. Hageman factor (factor XII) converts a proactivator to the active activator. Agents such as thrombin, streptokinase, and urokinase therefore enhance the formation of plasmin and hence have fibrin lytic properties. Epsilon-aminocaproic acid inhibits the activator-mediated formation of plasmin and hence may be used as an antidote to streptokinase-urokinase, or in a defibrination syndrome when bleeding from a mucous membrane occurs. 

Actively caring is planned and purposeful behavior, directed at environment, person, or behavior factors. It is reactive or proactive and direct or indirect. Direct, proactive, and behavior-focused active caring is most challenging, but it is usually most important for large-scale injury prevention. This chapter discusses conditions and situations that inhibit actively caring behavior. We need to understand why people resist opportunities to actively care for safety. Then, we can develop interventions to increase this desired behavior which is critical for achieving a Total Safety Culture. 

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