Inhibition of human cytochrome

Heidrich DD, Steckelbroek S, Klingmueller D (2001) Inhibition of human cytochrome P450 aromatase activity by butyltins. Steroids, 66 763—769. 

Fuhr U, Strobl G, Manaut F, Anders E-M, Sorgel F, Lopez-de-brinas E, et al. Quinolone antibacterial agents relationship between structure and in vitro inhibition of human cytochrome P450 isoform CYP1A2. Mol Pharmacol 1993 43 191-9. 

Kunze, K.L. and Trager, W.F. (1993) Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chemical Research in Toxicology, 6 (5), 649-656. 

Atkinson, A., Kenny, J.R. and Grime, K. (2005) Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. Drug Metabolism and Disposition, 33 (11), 1637—1647. 

Liu Y, Zhang IW, Li W et al (2006) Ginsenoside metabohtes, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. 1 Toxicol Sd 91 356-364... 

Walsky, R.L., Obach, R.S., Gaman, E.A., Gleeson, J.P. and Proctor, W.R. (2005) Selective inhibition of human cytochrome P4502C8 by montelukast. Drug Metabolism and Disposition The Biological Fate of Chemicals, 33, 413-418. 

Yu, C., Shin, Y.G., Kosmeder, J.W., Pezzuto, J.M., and van Breemen, R.B., Liquid chromatog-raphy/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun. Mass Spectrom., 17, 307, 2003. 

Zhai, S. et al.. Comparative inhibition of human cytochromes P450 lAl and 1A2 by flavonoids. 

Verhoeven CHJ, Vos RME, Bogaards JJP. Characterization and inhibition of human cytochrome P450 enzymes involved in the in vitro metabolism of mirtazapine. Presentation at International Symposium on Microsomes and Drug Oxidations, Los Angeles, July 21-24, 1996. 

Matthews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos 2002 30 1153-1157. 

Ginseng Much ado about nothing Consumer Reports, Nov. 1995 699. Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John s wort s, an herbal preparation used in the treatment of depression. J Pharmacol Expl Ther 2000 294 88-95. 

Table 2 Inhibition of Human Cytochrome P450 3A4-, P450 3A5-, and P450 3A7-Mediated Metabolism of the Marker Substrate 7-Benzyloxyresorufin by Aqueous Extractions of SJW Teas in the Fluorescence Plate Assay and Testosterone HPLC Assay (in Brackets) (n — 3 25mg/mL Stock Solutions % Inhibition SD)...

Table 3 Inhibition of Human Cytochrome P450-Mediated Metabolism by Aliquots of Aqueous Extracts of SJW Tablets (% Inhibition SD 5mg/mL Stock Solutions Except Where Noted n = 3-6)...

Shader RI, Granda BW, von Moltke LL, Giancarlo GM, Greenblatt DJ. Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast. Biopharm Drug Dispos 1999 20(8) 385-388. 

Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003 10(4) 334—342. 

Katoh M, Nakajima M, Shimada N, et al. Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol 2000 55 843-852. 

Mechanism-Based Inhibition of Human Cytochromes P450 In Vitro Kinetics and In Vitro-In Vivo Correlations... 

Mechanism-Based Inhibition of Human Cytochromes P450... 

Chun YJ, Ryu SY, Jeong TC, et al. Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug Metab Dispos 2001 29(4 pt l) 389-393. 

Chang TK, Gonzalez FJ, Waxman DJ (1994) Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch Biochem Biophys 311 (2) 437—442... 

Jones DR, Hall SD. Mechanism-based inhibition of human cytochromes P450 in vitro kinetics and in vitro-in vivo correlations. In Drug-Drug Interactions. Rodrigues AD, ed. 2002. Marcel Dekker, Inc. New York. pp. 387-413. 

Dai R, Zhai S, Wei X, Pincus MR, Vestal RE, Friedman FK. Inhibition of human cytochrome P450 1A2 by flavones A molecular modeling study. J Protein Chem 1998 17 643-50. 

---