Influence on Orthostatic Hypotension

Orthostatic hypotension with dizziness up to unconsciousness is a syndrome occurring in many human 

A significant increase in postural hypotension with respect to the control would indicate that the test compound may produce orthostatic hypotension in human. Moreover, some compounds, like sympathomimetics, can reduce or prevent postural hypotension. 

Methods for evaluating postural hypotension were described in conscious dogs (Baum et al. 1981), conscious rabbits (Sponer et al. 1981), in rats (Lee et al. 1982) and in cynomolgus monkeys during ketamine anesthesia (Pals and Orley 1983). 

Baum TH, Vliet GV, Glennon JC, Novak PJ (1981) Antihypertensive and orthostatic responses to drugs in conscious dogs. J Pharmacol Methods 6 21-32 Boura ALA, Green AF (1959) The actions of bretylium Adrenergic neuron blocking and other effects. Brit J Pharmacol 14 536-548 

Lee CH, Strosber AM, Roszkowski AP, Warren LA (1982) A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats. J Pharmacol Methods 7 15-24 

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