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Influence of Genetic Background

Holmes A, Lit Q, Murphy DL, Gold E, Crawley JN. Abnormal anxiety-related behavior in serotonin transporter null mutant mice the influence of genetic background. Genes Brain Behav 2003 2 365-380. [Pg.603]

Epidemiological, familial, and molecular studies of MS have supported a strong influence of genetic background on dis-... [Pg.241]

Linder, CC, The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases. Lab Anim (NY), 2001. 30(5) 34—39. [Pg.37]

Bilkei-Gorzo A, Schuetz B, Zimmer A (2001) Influence of the genetic background on the reactivity ofpre-proenkephaline knockout mice in models of anxiety. Soc Neurosci Abstr 955.9... [Pg.358]

As genetic background greatly influences behavioral phenotypes in mice, comparative studies must take this into account. The use of inbred mice substantially decreases within-subject variation and also provides valuable insight into the neurobiological mechanisms that modulate specific phenotypes. The most updated detailed nomenclature for mouse strains should be used, and mice should be obtained from certified vendors or other reliable sources to ensure comparability of results between laboratories. In contrast, outbred mice do not seem to present similar benefits, and therefore, may yield more confounded results. [Pg.314]


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Genetic background

Genetic influences

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