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Caspases inflammatory

Comelis S, Kersse K, Festjens N et al (2007) Inflammatory caspases targets for novel therapies. Curr Pharm Des 13 367-385... [Pg.334]

Inflammatory caspases (caspase-1, -4, -5,-11 and -12) constitute a subgroup of the caspase family. Caspase-1 is the best characterized member and is responsible for the proteolytic maturation and release of the pro-inflammatory cytokines pro-interleukin (IL)-1 (3 and pro-IL-18. Caspase-1 gets activated in inflammasome complexes upon cellular stress, cellular damage and infection. [Pg.630]

Inflammation Inflammatory Caspases Inflammatory Disorders Influenza... [Pg.1494]

Martinon F, Tschopp J. Inflammatory caspases Linking as intracellular innate immune system to autoinflammatory diseases. Cell 2004 117 561-574. [Pg.34]

Caspases belong to the family of cystein proteases that cleave adjacent to aspartate residues in the substrate. Fourteen mammalian caspases have been identified and divided into three classes. The first class is the inflammatory caspases, caspase 1,4,... [Pg.323]

The activation of the inflammatory caspases uses a mechanism resembling that of the initiator caspases. The presence of a complex, known as the inflammasome (Martinon et al., 2002), is required for activation of this set of proteases. The recruitment of caspases into this complex results in their activation. For caspase-1, the adaptor ASC (apoptosis-associated specklike protein containing a CARD) is critical in inflammasome formation in response to a variety of stimuli, whereas involvement of the adaptors Ipaf (ICE-protease-activating factor) and NALP3 is stimulus-dependent (Mariathasan, 2007). [Pg.23]

Martinon F, Burns K, Tschopp J (2002) The inllammasome a molecular platform triggering activation of inflammatory caspases and processing of prolL-beta. Mol Cell 10 417 26... [Pg.43]

Caspase 11 (ICH-3) Cytokine processing 1,3 7 Pro-inflammatory caspase involved in the caspase activation cascade. [Pg.143]

CD C14 C14.001 Caspase-1 Potential drug target for down-regulation of the inflammatory mediator, interleukin 1beta, which could ameliorate inflammation and endotoxic shock... [Pg.878]

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See also in sourсe #XX -- [ Pg.19 ]



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