Infectious disease hematopoietic stem cell transplantation

Steingrimsdottir H. Gruber A. Bjorkholm M. et al. Immune reconstitution after autologous hematopoietic stem cell transplantation in relation to underlying disease, type of high-dose therapy and infectious complications. Haematologica 2000,85,832-838. 

Sullivan KM, Dykewicz CA, Longworth DL, et al. Preventing opportunistic infections after hematopoietic stem cell transplantation The Centers for Disease Control and Prevention, Infectious Diseases Society of America, and American Society for Blood and Marrow Transplantation practice guidelines and beyond. Hematology (Am Soc Hematol Educ Program) 2001 392 21. 

Centers for Disease Control and Prevention. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients Recommendations of CDC, the Infectious Diseases Society of America, and the American Society of Blood and Marrow Transplantation. MMWR 2000 49(RR-10) 1-110. 

In addition to bone marrow and peripheral blood, hematopoietic stem cells are also found in umbihcal cord blood (UCB). UCB is an attractive source for several reasons. Because the stem cells are collected from placental blood, there is no risk to the mother or the baby. There is also very low risk of hansmissible infectious diseases such as cytomegalovhus and Epstein-Barr virus. In addition, the cells are available immediately because the donor does not have to be located and harvested. Initially, UCB was obtained from sibhngs but now recipients of transplants from unrelated donors accountfor almost all patients who receive UCB transplants. It is estimated that more than 2,000 unrelated UCB transplants have been performed worldwide. ... 

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