Infection time-concentration profile

Solutions (lavages) and foams are liquid preparations. The foams differ from the solutions in the presence of a suitable propellant, in the formulation, and the type of container, a pressurized delivery device. Plasma concentration profiles obtained after solution administration are characterized by a burst effect followed by a rapid decrease below therapeutic levels, due to the low residence time of the formulation in the vaginal cavity. Such preparations are designed to achieve a local effect particularly in case of inflammations or infections caused by bacteria or yeasts (anaerobic bacteria or Candida species). Nonoxynol-9 (N-9) foam is used as a contraceptive and against sexually transmitted diseases [19]. 

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