Infarct incomplete

Cautions Impaired renal function, impaired hepatic function, hypokalemia, advanced cardiac disease, acute myocardial infarction, incomplete AV block cor pulmonale, hypothyroidism, pulmonary disease... 

The neuromuscular complications of diabetes mellitus are most often neuropathic in origin, with distal sensorimotor polyneuropathies being the most common. In addition, ischemic infarction of skeletal muscle may occur due to occlusive vascular disease, with small and medium-sized arterioles particularly affected. This occurs in poorly-controlled diabetes and affects thigh, muscles in most cases. In acute stages, muscle biopsy findings are those of widespread muscle necrosis, edema, and phagocytic cell infiltration. Muscle regeneration may be incomplete and increased fibrous connective tissue may replace lost muscle tissue. 

Fig. 4.1. Frequency maps of two types of ischemic damage complete infarction (left) and scattered neuronal injury (right). Histology was obtained 24 h after left MCA occlusion in rats. Total number of animals was 9. Pseudocolor representation denotes the number of animals that showed the respective type of injury at this pixel. Note the widespread distribution of incomplete infarction over the affected left hemisphere. [Adapted from Alexis et al. (1996)]...

Lassen NA, Vorstrup S (1984) Ischemic penumbra results in incomplete infarction is the sleeping beauty dead Stroke 15 755... 

Garcia JH, Lassen NA, Weiller C, Sperling B, Nakagawara J (1996) Ischemic stroke and incomplete infarction. Stroke 27 761-765... 

Histopathological features of white matter lesions include diffuse myelin pallor (sparing the U-fibers, that are supplied by cortical branches), astrocytic gliosis, widening of perivascular spaces, and loss of oligodendrocytes leading to rarefaction, spongiosis, as well as loss of myelin and axons without definite necrosis, which has also been described as incomplete white matter infarction, which may finally... 

Slow and incomplete absorption of procainamide has been reported in patients with acute myocardial infarction and has been attributed to decreased splanchnic blood flow (26). Decreased splanchnic blood flow also may reduce the bioavailability of NAPA, the acetylated metabolite of procainamide. Although an explicit relationship between CLp and... 

Nowadays, CMR has demonstrated great accuracy in estimating infarcted mass (Horacek et al., 2006 Moon et al, 2004) (Figures 9.1 and 9.2), which makes this technique the gold standard for the quantification of infarction mass. However, recently, Engblom (2006) has reported that in patients with first time reperfused MI the QRS score is significantly related to both MI size and transmural-ity. Also, recently, it has been published that high QRS Selvester score is an independent predictor of incomplete ST recovery and complications in STE-ACS treated with primary PCI (Uyarel et al., 2006). 

Madias JE, Win M. Incomplete ECG expression of acute true posterior myocardial infarction, owing to an antecedent anterior infarction. J Electrocardiol 2000 33 189. 

Although earlier trials suggested that verapamil and diltiazem may provide improved benefit in selected patients, the large Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis post-Thrombolysis (INTERCEPT) has dampened the interest for the use of diltiazem in patients receiving fibrinolytics. In this trial, the use of extended-release diltiazem had no effect on the 6-month risk of cardiac death, MI, or recurrent ischemia. Therefore, the role of verapamil or diltiazem appears to be limited to relief of ischemia-related symptoms or control of heart rate in patients with supraventricular arrhythmias for whom /8-blockers are contraindicated or ineffective. ... 

INTERCEPT Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis post-Thrombolysis ISIS-1 First International Study of Infarct Survival ISIS-2 Second International Study of Infarct Survival IV intravenous LDL low-density lipoprotein LMWH low-molecular-weight heparin LVEF left ventricular ejection fraction MB myocardial band MI myocardial infarction... 

Boden WE, van Gilst WH, Scheldewaert RG, et al. Diltiazem in acute myocardial infarction treated with thrombolytic agents A randomised, placebo-controlled trial. Incomplete Infarction Trial of European Research Collaborators Evaluating Prognosis post-Thrombolysis (INTERCEPT). Lancet 2000 355 1751-1756. 

Fig. 5.8 Reversal of CTA-SI abnormality. A patient with a light M1 thrombus who had complete recanalization after 90 min following lAT There is a large MCA territory blood pool deficit on the CTA-SI (left, arrows), but only a small deep gray lenticular hypodensity on the postlysis unenhanced CT (right). Late follow-up showed lenticular infarct with minimal, patchy, incomplete infarction in other portions of the MCA territory (courtesy of Jeffrey Farkas, MD)...

Brown, B.G., Gallery, C.A., Badger, R.S., Kennedy, J.W., Mathey, D., Bolson, E.L. and Dodge, H.T. (1986). Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction quantitative angiographic observations. Circulation, 73, 653-661... 

Fig. 5.65a-f. Angiography before and after incomplete coil embolization of an un ruptured left MCA aneurysm. Due to progressive thrombosis out of the aneurysm gradual MCA occlusion developed 4.5 h after the intervention. The vessel could be reopened by selective intraarterial thrombolysis using urokinase (1,000,000 lU). Although a small basal ganglia infarction was induced the patient had a good recovery with only mild deficits... 

Suzuki J, Komatsu S, Sato T, Sakurai Y (1980a) Correlation between CT findings and subsequent development of cerebral infarction due to vasospasm in subarachnoid haemorrhage. Acta Neurochir (Wien) 55 63-70 Suzuki J, Kwak R, Katakura R (1980b) Review of incompletely occluded surgically treated cerebral aneurysms. Surg Neurol 13 306-310... 

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