Induction genome mutation

Multidrug resistance (Mdr) is a serious problem in enteric and other Gramnegative bacteria [41, 71, 273-283] (Table 4.17). As distinct from plasmid-mediated resistance, described above, Mdr is a term employed to describe a resistance mechanism by genes that comprise part of the normal cell genome. These genes are activated by induction or mutation caused by some types of stress, considered below. Because the genes are ubiquitously distributed, there is no need for genetic transfer. 

M. Fukunaga, Y. Mizuguchi, L. W. Yielding and K. L. Yielding, Petite induction in Saccharomyces cerevisiae by ethidium analogs. Action on mitochondrial genome, Mutat. Res., 1984, 127, 15-21. 

The platinum-DNA adduct that is the major source of mutation induction by cis-DDP is a matter of controversy. One study (17) found platinated d(GpNpG) sequences to be the most mutagenic loci for base pair substitution. Another (18) reported that d(ApG) and d(GpG) cross-links accounted for 90% of single base pair mutations, and that d(ApG) crosslinks were five times more mutagenic. This conflict may be due to the different systems used for these studies, and the range of mutations they detect. Site-specifically modified M13 genomes were constructed in part to answer the question of the mutability of individual platinum-DNA adducts... 

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