Induced-fit theory

Koshland DE Jr. The key-lock theory and the induced fit theory. Angew Chem Int Ed Engl 1994 33 2375-8. 

Figure 25-18 Illustration of the lock-and-key concept of enzyme-substrate Interaction (top) and of the induced-fit theory, whereby the enzyme molds to the substrate through conformational changes (bottom)...

Complexation could occur in many different ways, but for the intimate com-plexation required for catalysis, the enzyme must have, or must be able to assume, a shape complementary to that of the substrate. Originally, it was believed that the substrate fitted the enzyme somewhat like a key in a lock this concept has been modified in recent years to the induced-fit theory, whereby the enzyme can adapt to fit the substrate by undergoing conformational changes (Figure 25-18), Alternatively, the substrate may be similarly induced to fit the enzyme. The complementarity is three-dimensional, an important factor in determining the specificity of enzymes to the structure and stereochemical configuration of the substrates. 

Personal reminiscences in macromolecular and protein chemistry have been recorded.205 Both D. E. Koshland206and J. T. Edsall207 have reported their own experiences in early protein research, the former stressing his induced fit theory and the latter describing his long career at Harvard after two years with Hopkins at... 

D. E. Koshland and J. T. Edsall have recorded their own experiences in early protein research. Koshland stresses the value of his induced fit theory,192 while Edsall describes his long career at Harvard after two years with Hopkins at Cambridge.193 Fruton has also described the work of T. B. Osborne (1859-1928), noted for his analyses of amino-acids from seed proteins.194 The idea that enzymes might be proteins was a matter of heated debate among chemists from about 1915, including arguments between Willstatter and James Sumner, who in 1926 isolated the enzyme urease and showed it to be a protein.195 However, while it is most important to emphasize protein chemistry, the contributions made to protein science by physics... 

The elegance of enzyme reactivity is unparalleled in synthetic catalytic materials. Beginning from ilic time slicn liinil l isclicr proposed his classic lock-and-kcy theory for enzyme specificity to the induced fit theory of Koshland, enzyme catalysis sets the standard to which all other catalytic transformations are compared. 

Koshland s Induced-fit Theory, 186 Kreb s Tea Cycle, 297 Kreb s Urea Cycle, 433... 

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