Indole-3-carboxylic acid methylated

Indole-3-carboxylic acid methyl ester A. cucurbitifolia 56... 

Pyrrole- and indole-carboxylic acid chlorides react with dialkyl- and diaryl-cadmium to yield the ketones and it is noteworthy that the reaction of the anhydride of indole-2,3-dicarboxylic acid with diphenylcadmium produces 3-benzoylindole-2-carboxylic acid and not its isomer (53JCS1889). The ability of l-methylindole-2-carboxylic acid to react with nucleophiles is enhanced by conversion into the mixed anhydride with methanesulfonic acid. The mixed anhydride reacts with carbanions derived from diethyl malonate and from methyl acetate to yield the indolyl (3- keto esters (80TL1957). 

To a solution of the S-(+)-4-acethoxy-9-[2-(5-ethyl-l,2,3,6-tetrahydro-pyridin-3yl)-l-(lH-indol-2-yl)-l-methoxycarbonyl-ethyl]-3a-ethyl-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,ll,12,12b-octahydro-lH-6,12a-diaza-indeno[7,l-ca]fluorene-5-carboxylic acid methyl ester in dioxane and glacial acetic acid was added 37% aqueous formaldehyde and the mixture stirred at 35°C for 24 h. The solution was evaporated in vacuo and the residue suspended in chloroform and washed with cold aqueous 5% K2C03 solution. The chloroform layer was dried (MgS04), filtered, and evaporated. The residue was chromatographed eluting with EtOAc/MeOH, 10% NH4OH to give the product navelbine. 

The position of the sugar residue in the dihydroindole portion can be determined by methylation of the pigment with diazomethane and subsequent alkaline degradation of the resulting neobetanin derivative. In the case of 5-0-glycosides, 5-hydroxy-6-methoxyindole-2-carboxylic acid is obtained, whereas the 6-O-glyco-sides yield 6-hydroxy-5-methoxyindole-2-carboxylic acid (47,48). The indole carboxylic acids are easily identified by TIjC. 

Yohimbine, (16a,I7a) 17-Hydroxyyohimban-I6-carboxylic acid methyl ester quebrachine corynine aphro-dine, C, HuNiOJ mol wt 354.43. C 71.16%, H 7,39%, N 7.90%, O 13.54%. Indole alkaloid with a,-adrenergic blocking activity. Found in Corynanthe johimbe K. Schum., Rubiaceae and related trees, also in Rauwolfla serpentina (L.) Benth., Apocynaceae Raymond -Hamet. J. Pharm. Chim. 

An indole-derived alkaloid Synonyms (16a, 17a )-17-hydroxyyohimban-16-carboxylic acid methyl ester corynine aphrodine quebrachine... 

In addition to the reagents for detection which are quoted in Table 88, many others have been mentioned in the literature [89, 90, 104] for urine metabolites [78] for serotonine metabolites [14] for hydroxyindoles and -tryptophans [35] with comprehensive data for hydroxyskatoles [19] for the methyl esters of indole-carboxylic acids [i2, 23, 63] for glucobrassicin. 2,4-Dinitrophenylhydrazine (Rgt. No. 82) is suitable for the often feebly reactive indole-aldehydes. 

C111H15N3O5 0.5 CH4O, 3-Carbamoyl-1,2-dihydro-4-hydroxy-5-methoxy-3H-pyrrolo[3,2-e]indole-7-carboxylic acid methyl ester methanol solvate, 44B, 255... 

Indole-2-carboxylic acid, 3-methyl-ethyl ester... 

A -Methylation of the NH of heterocycles using 1 is also known as exemplified by the methylation of indole/ The interesting mechanism is delineated below. O-methylation of weak acids such as phenols, carboxylic acids and oximes as well as 5-methylation such as A -phenylisorhodanine, certain thioketones, and dithiocarboxylic acids have also been reported." ... 

The first indolization of an arylhydrazone was reported in 1983 by Fischer and Jourdan" by treatment of pyruvic acid 1-methylphenylhydrazone 3 with alcoholic hydrogen chloride. However, it was not until the following year that Fischer and Hess identified the product from this reaction as 1-methyl indole-2-carboxylic acid 4. 

Indole, 1-methyl-, 40, 68 Indole-3-carbonttrile, 43, 58 Indoie-3-carboxaldehyde, conversion to indole-3-carbonitrile, 43, 58 Indole-2-carboxylic acid, ethyl ester, 43, 40... 

CN i//-Indole-3-carboxylic acid endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester... 

C jH2,NOSi) see Indanorex (lS-cii)-2,3-dihydro-l//-indene-l,2-diol (G7H10O2 6752S-22-7) see Indinavir sulfate (laS)-la,6a-dihydro-6//-indenori,2-6]oxirene (CgHjO 67528-26-1) see Indinavir sulfate (2,3-dihydro-l//-inden-4-yl)carbamimidothioic acid methyl ester monohydriodide (C, H 1N2S 40507-77-5) see Indanazoline 23-dibydro-l//-indole-2-carboxylic acid ethyl ester (C iH, N02 50501-07-0) see Perindopril... 

Biochemical tests are usually performed after pure cultures have been obtained. The standard indole, methyl red, Voges-Proskauer, citrate, and litmus milk tests may be used to show important physiological characteristics. To study the functional diversity of bacteria, the utilization of carbohydrates, amines, amides, carboxylic acids, amino acids, polymers, and other carbon and nitrogen sources can be tested.28 Dilution-based most-probable number (MPN) techniques with phospholipid fatty acids as biomarkers have been employed for studying different bacterial species in lakes.40 The patterns of antibiotic resistance in bacteria isolated from natural waters have been useful for identifying sources of water pollution.34... 

Esters of 2-(2-azidophenyl)ethyl alcohol are photolyzed under a high-pressure mercury lamp to a reactive nitrene intermediate which, following insertion into the alkyl side-chain, undergoes elimination to give the free carboxylic acid (up to 32%) and producing indole. The photochemical release was somewhat improved (65-80%) when 5-azido-4-(hydroxy-methyl)-l-methoxy naphthalene was used (see Scheme 27). 

In addition, iodine snccessfnlly catalyzed the electrophilic snbstitntion reaction of indoles with aldehydes and ketones to bis(indonyl)methanes [225], the deprotection of aromatic acetates [226], esterifications [227], transesterifications [227], the chemoselective thioacetalization of carbon functions [228], the addition of mercaptans to a,P-nnsatnrated carboxylic acids [229], the imino-Diels-Alder reaction [230], the synthesis of iV-Boc protected amines [231], the preparation of alkynyl sngars from D-glycals [232], the preparation of methyl bisnlfate [233], and the synthesis of P-acetamido ketones from aromatic aldehydes, enolizable ketones or ketoesters and acetonitrile [234],... 

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