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Indolactam library

For building up a library around a given core structure many examples have been given, e.g. an Indolactam library by Waldmann et al. [11], a Sarcodictyin-based library by Nicoloau et al. [12] and a Taxoid library by Xiao et al. [13]... [Pg.397]

Figure 15.10 Solid-phase synthesis of indolactam library by Waldmann s laboratory [34, 35]. Figure 15.10 Solid-phase synthesis of indolactam library by Waldmann s laboratory [34, 35].
Meseguer,B., Alonso-Dfaz,D.,Griebenow,N.,Herget,X.,Waldmann,H. Natural product synthesis on polymeric supports-synthesis and biological evaluation of an indolactam library. Angew. Chem. Int. Ed. 1999, 38, 2902-2906. [Pg.208]

The full combinatorial exploitation of 3.68 requires an assessed SP synthetic method to build the indolactam scaffold and to generate an SP library. [Pg.115]

Exploitation of the SP route Three steps were identified to build a combinatorial SP route to indolactam-inspired libraries (Fig. 3.29) ... [Pg.117]

An additional two points of diversity were incorporated via reductive amination, followed by selective iodination that enabled Sonogashira couphng to give 382. Final treatment cleaved the products, but with unexpected hydration of the alkyne functionality, to yield 383 and a corresponding 12-membered library of indolactam V analogs. [Pg.110]

SCHEME 3.65. Solid-phase synthesis of an indolactam V library. [Pg.110]


See other pages where Indolactam library is mentioned: [Pg.77]    [Pg.217]    [Pg.77]    [Pg.217]    [Pg.415]    [Pg.616]    [Pg.299]    [Pg.110]   
See also in sourсe #XX -- [ Pg.397 ]




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