Indinavir Orange juice

Penzak SR, Acosta EP, Turner M, et al. Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J Clin Pharmacol 2002 42(10) 1165-1170. 

Grapefruit juice does not have any clinically significant effects on the pharmacokinetics of either amprenavir or indinavir. Although the saquinavir AUC was doubled by grapefruit juice, these increases are not thought to be clinically relevant Seville orange juice did not alter indinavir pharmacokinetics. 

---