INDEX diterpenes

In the past 20 years hundreds of Chinese traditional and herbal medicines with immunomodulating functions have been screened, and their active components studied. Through these studies, six diterpene lactone epoxide compounds, with antiinflammatory and immunosuppressive actions, were isolated from T. wilfordii. Zheng et al. [183] assayed the half-effective dose (ED50), the therapeutic index (TI) and a certain safety factor (CSF) using croton oil induced ear swelling and hemolysin-antibody formation mouse models and found that triptolide (79), tripdiolide (80), triptonide (81), tripchlorolide (92), and triptolidenol (93) possessed both antiinflammatory and immunosuppressive activities, while triptriolide (94) showed antiinflammatory action only. Fig. (28). The results of the TI and CSF of both activities clearly demonstrated that the antiinflammatory and immunosuppressive compounds in T. wilfordii are pluralistic and the differences in these compounds can be used as a base for the evaluation and selection of them. 

Thus we assign a basic class number of 54 (diterpenes) and on p. 384 we find the main entry with number 54.6. In the formula index it will appear as C20H28O4, C2H6O 54.6. 

Table 3 (pp. 150-218) lists all diterpene compound numbers, the species of the Compositae from which they were reported and the reference numbers for the reports. Species names complete with authorities are listed alphabetically in the Species Index. 

The Nobd Prize in Chemistry 1990. Professor E.J. Corey for his development of the theory and methodology of organic synthesis . http //www.marinespedes.org/index.php Worms, world Register of Marine Species. http //dcb-carot.unibe.ch/homepages /daniel /XENlintro.htm Xenicanes. Site dedicated to this particular family of diterpenes (xenicanes). 

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