Indeno pyridazines

J. Wouters, Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-indeno[1,2-c]pyridazin-5-one derivative, Bioorg. Med. Chem. Lett. 13 (2003) 69-73. 

B. Testa, Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines Biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs, J. Med. Chem. 38 (1995) 3874-3883. 

Diazine A -oxides can be regioselectively formed with H2O2 in formic acid as exemplified by the reaction of 2-chlorobenzo[/]cinnolines, 2-chloro-5,6-dihydrobenzo[/]cinnolines, and 3-chloro-9//-indeno[2,l-f]pyridazines <2000AP341>. This area was extensively discussed in CHEC(1984) <1984CHEC(2)1>. 

In general, pyrolysis of monocyclic 1,2,3-triazines 1 leads to acetylenes, nitriles and nitrogen.46, 295 297 300 Heating simple 1,2,3-triazines in a sealed tube led to the isolation of pyridines, pyrimidines, pyrazoles, pyrroles, pyridazine, and indeno[3,2-/>]pyridine, depending on the substituents bound to the 1,2,3-triazine ring and the reaction conditions.46 A mechanism formulated for the formation of these products involves an azete as an intermediate. 

Thiocarbohydrazide 110 and 3 yielded 1-amino indeno[l,2-c]pyrazolo-[4,3-e]pyridazin-10(lH)-one 112 via the formation of 111 as an intermediate (Scheme 36,1997M61). 

Campagna f, Palluoto F., Mascia M.P. Synthesis and biological evaluation of pyridazino[4,3-b]indoles and indeno[l,2-c]pyridazines as new ligands central and peripherial benzodiazepine receptors . - Farmaco, 2003, v. 58, p. 129-140. 

Campagna F., Palluotto F., Carotti A. and etc. Synthesis and structure-affinity relationships at the eentral benzodiazepine receptor of pyridazino[4,3-b]indoles and indeno[l,2-e]pyridazines. - Bioorganic and Medicinal Chemistry, 1999, V. 8, JVo 12, p. 1533-1538. referatebi, gverdi 6... 

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