Inclusion mechanism

Quantitative Structure-Reactivity Analysis of the Inclusion Mechanism by Cyclodextrins... 

Matsui, Y., Nishioka, T., and Fujita, T. Quantitative Structure-Reactivity Analysis of the Inclusion Mechanism by Cyclodextrins. 128, 61-89 (1985). 

The alternative mechanism, involving dimerization of the guest prior to inclusion, is unable to fit the observed data. Using the method of Bernas-coni or Czerlinski - the following equation can be derived, characterizing the variation of 1/t with cyclodextrin and guest concentrations for the aforementioned stepwise-inclusion mechanism,... 

Fig. 9.—Schematic Diagram of the Two Hosts-Two Guests Inclusion Mechanism Shown for the Tropaeolin 000 No. 2-Gamma Cyclodextrin System.

In a recent review of pharmacokinetics in drug discovery, Ruiz-Garcia et al. [81] compiled an exhaustive list of software resources for absorption prediction. The main topic in the described databases is transporters, in particular the ATP-binding cassette, of which the efflux transporter P-gp and the peptide transporter PEPTl are well known examples. These examples show that science is moving away from the simplistic passive transport view of permeability and towards an all-inclusive, mechanism-understanding model of absorption, which takes account of all the interactions between the agents involved in the specific permeation process. 

Abou-Hamdan, A. Bugnon, P. Saudan, Ch. Lye, P.G. and Merbach, A.E. (2000) High-Pressure Studies as a Novel Approach in Determining Inclusion Mechanisms Thermodynamics and Kinetics of the Host-Guest Interactions for a-Cyclodextrin Complexes, J. Am. Chem. Soc. 122, 592-602. 

Type II sorbents are based on an inclusion mechanism. Chiral recognition by optically active polymers is based solely on the helicity of that polymer. Optically active polymers can be prepared by the asymmetric polymerization of triphenylmethyl methacrylate using a chiral anionic initiator [264]. Helical polymers are unique from the previously discussed chromatographic approaches because polar functional groups are not required for resolution [265]. These commercially available sorbents have been used to resolve enantiomers of a-tocopherol [266]. The distinction between this group (lib) and the sorbents containing cavities is vague (Ila). 

The use of chiral stationary phases (CSP) is a technique that relies on the formation of transient, temporary diastereoisomers between the sample enantiomers and the chiral stationary phase.1 Differences in stability between the diastereoisomers are reflected in differences in retention times the enantiomer that forms the least stable complex is eluted first. Chiral stationary phases may be classified into five different groups on the basis of mechanism of retention 77 (1) chiral phases with cavities78 80 (inclusion mechanism), shown in Figure 2.19, (2) chiral affinity phases,81,82 (3) chiral phases based on multiple hydrogen bond formation,83 (4) chiral jr-donor and... 

Figure 2.19 Inclusion mechanism of retention for mephobarbital in cyclodextrin. (Reprinted...

Massey, A.H. (2002). Air Inclusion Mechanisms and Bubble Dynamics in Intermediate Viscosity Food Systems. School of Food Biosciences. University of Reading, Reading. 

---