Inactive drug

There are only two ways in which two drugs can interact to produce a result that is not obvious from the summing of their individual actions. One is the process of synergism, where two active materials are allowed to interact within a single individual and at one time, and the consequence of this interaction is different than that which would have been expected. The other is the process of potentiation, where only one drug is active, but the presence of the second (and inactive) drug enhances the observed action of the first. MDE seems to fall in the first category. 

Prodrugs Inactive drugs that undergo metabolic activation. 

As a negative dataset, 5000 CNS-inactive drugs were randomly selected from 50025 molecules from the WDI. For both the ANN training and the SUBSTRUCT classification, 3678 molecules (CNS-h) and 5000 molecules (CNS-) were used. 

I have been told of an experiment with the dextro-isomer of DOM (this is the inactive optical isomer) at a level that was, not surprisingly, without any effects. The researcher had a severe reaction the following day with what was referred to as "poor" hashish. A similar form of potentiation has been commented upon under the recipe for TOMSO, where an inactive drug, and a most modest amount of alcohol, add together to create an unexpectedly intense... 

But the fallout of this study was the uncovering of an unusual property that alcohol can occasionally have when it follows the ingestion of certain inactive drugs. Or if it is used at the tail end of an experience with an active drug. Usually some alcohol has been employed as a softener of the residual effects of the day s experiment, or as a social habit to accompany the post-mortem discussions of a day s experiences, and perhaps as a help to sleeping. But if there is a rekindling of the effect, rather than the sedation expected, then the verb "to tomso" can be used in the notes. It represents the promotion of an inactive situation into an active one, with the catalysis of alcohol. But the effect is not that of alcohol. 

Germ line KI (inactive drug-binding site) Complete KO in all tissues Preserves scaffolding function and more relevant to pharmacological inhibition. Can be embryonic lethal Potential confounding developmental effects... 

Table 3. Functionalization of Polar-ographic Inactive Drugs (1). [Oelschlager and Coworkers 1963-1982] ... 

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