In diarrhetic shellfish poisoning

Murata, M., Isolation and structure of yessotoxin, a novel polyether compound implicated in diarrhetic shellfish poisoning, Tet. Lett., 28, 5869, 1987. 

Yessotoxin (214) is a polyether from the scallop Patinopecten yessoensis and has been implicated in diarrhetic shellfish poisoning (DSP). The structure and partial stereochemistry of yessotoxin were deduced from spectral data [219]. The relative stereochemistry of yessotoxin and the structures of two new analogues, 45-hydroxyyessotoxin (215) and 45,46,47-trinoryessotoxin (216) were also established [220]. The absolute stereochemistry of yessotoxin (214) was determined by NMR spectroscopy using a chiral anisotropic reagent [221]. The absolute configuration at C45 in 45-hydroxyyessotoxin (215), isolated from P. yessoensis, was determined by the use of a modified Mosher s method [222]. 

Mori, Y, and Hayashi, H. 2002. Synthetic studies of yessotoxin, a polycyclic ether implicated in diarrhetic shellfish poisoning convergent synthesis of the BCDE ring system via an alkyne intermediate. Tetrahedron 58, 1789-1797. 

Takahashi, H., Kusumi, T, Kan, Y., Satake, M., and Yasumoto, T. 1996. Determination of the absolute configuration of yessotoxin, a polyether compound implicated in diarrhetic shellfish poisoning, by NMR spectroscopic method using a chiral anisotropic reagent, methoxy-(2-naphthyl)acetic acid. Tetrahedron Letters 37, 7087-7090. 

Draisci, R., Giannetti, L., Lucentini, L., Marchiafava, C., James, K.J., Bishop, A.G., Healy, B.M., and Kelly, S.S. 1998. Isolation of a new okadaic acid analogue from phytoplankton implicated in diarrhetic shellfish poisoning. J. Chromatogr. A, 798, 137-145. 

Suarez-Gomez, B., Souto, M. L., Cruz, P. G., and Fernandez, J. J. (2005) New targets in diarrhetic shellfish poisoning control. Journal of Natural Products, 68, 596-599. 

Murata, M., Kumagai, M., Lee, J.S., and Yasumoto, T., Isolation and stmcture of yessotoxin, a novel polyether compound imphcated in diarrhetic shellfish poisoning. Tetrahedron Lett., 28, 5869, 1987. Ogino, H., Kumagai, M., and Yasumoto, T., Toxicologic evaluation of yessotoxin, Nat. Toxins, 5, 255, 1997. 

Marcaillou-Le Baut, C., Toxins involved in diarrhetic shellfish poisoning DSP, Oceanis, 16, 359, 1990. 

---