Improved Tissue Uptake with Metal Chelation

6 Improved Tissue Uptake with Metal Chelation 

The water-insoluble vanadyl complex naglivan [bis(iV-octylcysteineamide) oxo-vanadium(iv)] has been given to STZ-diabetic rats in a suspension of 3% acacia gum by oral gavage. Naglivan doses of 0.1-0.3 mmol kg day effective- 

VP [bis(pyrrolidine-JV-carbodithioato)oxovanadium(iv)] was initially tested as an in vitro insulin mimetic by inhibition of free fatty acid release from rat adipocytes. It was administered orally to STZ diabetic rats at an initial dose (for 2 days) of 0.2 mmol kg day to achieve normoglycemia, followed by a maintenance dose of 0.1 mmol kg day Intraperitoneal administration of 

A series of dihydroxamic acid chelators have been designed as hydrophobic carriers of vanadyl. In an assay of lipogenic stimulation in rat adipocytes, RL-252 was maximally effective at molar ratios of 10 1 vanadyl sulfate chelator, suggesting a shuttle mechanism of action. These compounds were electrically neutral, lipid-soluble, and optically chiral they released the bound metal ion when treated with aqueous glutathione solutions. 

Combinations of vanadium and other trace elements have also been studied as a way to potentiate the action of vanadium. Pancreatectomized rats treated with a low concentration of oral sodium vanadate (0.5 gl ) and lithium carbonate 

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