Dihydroxamic acid

Figure 11. Isokinetic relationship for the Lossen rearrangement of dihydroxamic acids (208), in the log kj versus log k, plot, real (full line) and apparent (broken line) relations.

Synthetic linear dihydroxamic acids may be considered as models of rhodotorulic acid (3) to investigate steric effects on the formation of mono- or di-iron(III) species (127,128). pH-dependent electrospray ionization-mass spectrometry (ESI-MS) methods show that ferric complexes with dihydroxamates with short linker chains (37 and 38 in Fig. 15) will prefer the dimeric... 

Fig. 15. Linear dihydroxamic acid siderophore mimics with alkyl connecting chains.

A combination first coordination shell-second coordination shell based recognition BLM transport system was devised, including active transport (200). This is based on a labile dihydroxamic acid system, including alcaligin, and a free lysine hydroxamic acid ligand capable of ternary complex formation to... 

Atkin CL, Neilands JB (1968) Rhodotorulic Acid, a Diketopiperazine Dihydroxamic Acid with Growth-Factor Activity. I. Isolation and Characterization. Biochemistry 7 3734... 

The dihydroxamic acid polymer containing carboxylic acid groups as well as hydroxamic acid groups was used to examine the adsorptivity for uranium in seawater the adsorptivity was 40 pg/g resin in 8 days116). 

Among natural products the two well established members of the dihydroxamic acid class are the mycobactins and mycelianamide. The myco-bactins contain a third pair of atoms capable of coordinating iron and the resulting complex is thought to have biological significance (125). Mycelianamide is a cyclic anhydride of Na-hydroxyamino acids and, as... 

Simple complexes of hydroxamic acids with vanadium(V) have been reported, including ones with a variety of nuclearities.249,250 A wide range of TV-substituted mono- and dihydroxamic acids undergo oxygen abstraction upon reaction with V111 and Vlv to form Vv hydroxamate complexes and the respective amides and diamides.251... 

To provide the free acid, the salt (17 g) is treated with the calculated amount of alcoholic hydrogen chloride (50 ml, 2.8 n) and set aside for 2 h with occasional shaking. Filtration from the separated sodium chloride and removal of the alcohol in a vacuum (25°) afford the crude dihydroxamic acid, m.p. 144-147° the pure acid melts at 155°. 

A series of dihydroxamic acid chelators have been designed as hydrophobic carriers of vanadyl. In an assay of lipogenic stimulation in rat adipocytes, RL-252 was maximally effective at molar ratios of 10 1 vanadyl sulfate chelator, suggesting a shuttle mechanism of action. These compounds were electrically neutral, lipid-soluble, and optically chiral they released the bound metal ion when treated with aqueous glutathione solutions. 

DL-Homo-Cyst dihydroxamic acid a,-r-Diaminobutyric acid 190-195 IR 327... 

Dihydroxamic acids were synthesised from dicarboxylic acids via formation of the corresponding di-imidazolides on reaction with carbonyl diimidazole, followed by subsequent treatment with... 

Unlike hydroxamic acids, A -hydroxyimides form stable 0-phosphoryloxy and O-sulfonyl derivatives. These hydroxyimides can be prepared from hydroxamic acid and isocyanates. As an example, cyclic A/-hydroximide 22 was prepared from dihydroxamic acid 20 through Lossen rearrangement and followed by self-condensation of intermediate 21. 

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