Inosine monophosphate, IMP

AMP, ADP, and ATP = adenosine mono-, di-, and triphosphate IMP = inosine 5 -monophosphate AICAR = 5 -phosphoribosyl-5-amino-4-imida2olecarboxamide DAP = diaminopimelic acid PRPP = phosphoribosyl pyrophosphate a — KGA = a-ketoglutaric acid Orn = ornithine Cit = citnilline represents the one carbon unit lost to tetrahydrofolate as serine is converted to glycine. 

Figure 1. Nucleotide degradation pathway (ATP=adenosine-5 -triphosphate, ADP=adenosine-5 -diphosphate, AMP=adenosine-5 -monophosphate, IMP=inosine-5 -monophosphate).

Abbreviations 2-AP = 2-aminopyridine a-La = a-lactoalbumin P-Lg = P-lacto-globulins CAPS = 3-[cycloheylamino]-1-propane-sulfonic acid CN = caseins DMF = dimethylformamide HIBA = a-hydroxyisobutyric acid Hx = Hypoxanthine HxR = inosine ID = inner diameter IMP = inosine 5 -monophosphate MeOH = methanol MHEC = methylhydroxycellulose PA = polyacrylamide PEG = polyethylene glycol PBS = phosphate buffered saline PTFE = polydetrafluoroethylene. 

FIGURE 50-3 Intracellular activation of nucleoside analog reverse transcriptase inhibitors. Drugs and phosphory-lated anabolites are abbreviated the enzymes responsible for each conversion are spelled out. The active antiretroviral anabolite for each drug is shown in the blue box. Key ZDV, zidovudine d4T, stavudine ddC, dideoxycytidine FTC, emtricitabine 3TC, lamivudine ABC, abacavir ddl, didanosine DF, disoproxil fumarate MP, monophosphate DP, diphosphate TP, triphosphate AMP, adenosine monophosphate CMP, cytosine monophosphate dCMP, deoxycytosine monophosphate IMP, inosine 5 -monophosphate PRPP, phosphoribosyl pyrophosphate NDR, nucleoside diphosphate. 

Abbreviations used are PP-ribose-P, a-5-phosphoribosyl-1-pyrophosphate PRA, 3-5-phosphoribosyl-l-amine GAR, glycinamide-ribonucleotide formyl-GAR, a-formyl-GAR formyl-GAM, a-formyl gly-cinamidineribonucleotide IMP, inosine 5 -monophosphate AMP, adenosine 5 -monophosphate GMP, guanosine 5 -monophosphate PPi, inorganic pyrophosphate CoA-SH, reduced coenzyme A NADP, nicotinamide adenine dinucleotide phosphate PRT, hypoxanthine-guanine phosphoribosyltransferase. 

A search in the Cambridge Structural Database revealed that the nucleotide complexes [Mn(H20)5(5-GMP)] 2H2O (5-GMP guanosine-5 -monophosphate) and [Mn(H20)5(5-IMP)] 2H2O (5-IMP inosine-5 -monophosphate) are rare examples of structurally characterized compounds in which an isolated nucleobase... 

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